RADIESSE® and RADIESSE® (+) are next-generation cosmetic dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth). RADIESSE® has small microspheres suspended in a gel-like solution comprised of calcium hydroxylapatite, a substance naturally found in the body. For the first three months, it acts as a cosmetic filler, plumping the skin and diminishing age lines. The microspheres, inducing new tissue development by stimulating collagen growth, provide extended results that can last up to two years. RADIESSE® has been useful in the treatment of facial lip atrophy, maxillofacial defects, as well as correcting scars, chin dimples and recently, volume loss in the back of the hands.